3-Bromo-5-fluoroisonicotinonitrile

Name: 3-Bromo-5-fluoroisonicotinonitrile
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1353636-66-4
Cat. No. CS-0042829
Molecule weight201.00
Purity≥98%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Bromo-5-fluoroisonicotinonitrile|CS-0042829

Structure of 1353636-66-4

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 1353636-66-4
Cat. No. CS-0042829
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂BrFN₂
Molecular Weight 201.00
Synonym(s) 3-bromo-5-fluoropyridine-4-carbonitrile
SMILES N#CC1=C(F)C=NC=C1Br

Description

3-Bromo-5-fluoroisonicotinonitrile features a strategically positioned bromine and fluorine substituent on an isonicotinonitrile scaffold, enabling selective cross-coupling reactions. The electron-deficient pyridine ring enhances reactivity in palladium-catalyzed transformations, while the nitrile group provides a handle for downstream functionalization. This bench-stable intermediate supports efficient synthesis of bioactive heterocycles and advanced pharmaceutical building blocks.

Application

3-Bromo-5-fluoroisonicotinonitrile serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogenation pattern. The nitrile group provides a handle for downstream functionalization, while the fluoro and bromo substituents offer complementary reactivity for sequential derivatization. Its bench-stable nature and compatibility with standard synthetic protocols make it ideal for constructing heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 36.68
LogP 1.85488
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

3-Bromo-5-fluoroisonicotinonitrile sigma3-Bromo-5-fluoroisonicotinonitrile manufacturer3-Bromo-5-fluoroisonicotinonitrile price3-Bromo-5-fluoroisonicotinonitrile structure3-Bromo-5-fluoroisonicotinonitrile SDSbuy 3-Bromo-5-fluoroisonicotinonitrile3-Bromo-5-fluoroisonicotinonitrile supplier3-Bromo-5-fluoroisonicotinonitrile uses3-Bromo-5-fluoroisonicotinonitrile molecular weightprice of 3-Bromo-5-fluoroisonicotinonitrile3-Bromo-5-fluoroisonicotinonitrile chemical name formula of 3-Bromo-5-fluoroisonicotinonitrile

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

3-Bromo-5-fluoroisonicotinonitrile

CAS No. 1353636-66-4

Recommended Products