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CS-W001157 4
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N3-PEG4-C2-Pfp ester

  • CAS No. 1353012-00-6

  • Cat. No. CS-0105087
  • Purity≥97%
  • MDL No.MFCD20926373

*For research and further manufacturing use only, not for direct human use.

N3-PEG4-C2-Pfp ester|CS-0105087

Structure of 1353012-00-6

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General Information

  • CAS No. 1353012-00-6
  • Cat. No. CS-0105087
  • Purity ≥97%
  • MDL No. MFCD20926373
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₂₀F₅N₃O₆
  • Molecular Weight 457.35
  • Synonym(s) None
  • SMILES O=C(OC1=C(F)C(F)=C(F)C(F)=C1F)CCOCCOCCOCCOCCN=[N+]=[N-]

Description

N3-PEG4-C2-Pfp ester features a reactive pentafluorophenyl ester group for efficient amide bond formation, paired with a short PEG4 spacer and a terminal azide for bioorthogonal conjugation. This bifunctional reagent enables site-specific labeling of proteins and biomolecules under mild conditions, combining excellent solubility with stability in aqueous environments.

Application

N3-PEG4-C2-Pfp ester serves as a versatile, bifunctional linker for site-specific conjugation in synthetic chemistry. The azide group enables efficient copper-free click reactions with alkynes, while the pentafluorophenyl (Pfp) ester readily reacts with primary amines under mild conditions. The PEG4 spacer provides enhanced solubility and reduced aggregation, making it ideal for bioconjugation workflows. This reagent offers excellent stability, ease of purification, and compatibility with diverse functional groups in peptide, oligonucleotide, and small-molecule modifications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   111.98
  • LogP   3.0543
  • H_Acceptors   7
  • H_Donors   0
  • Rotatable_Bonds   16

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