5-Bromoimidazo[1,2-a]pyridin-2-amine

Name: 5-Bromoimidazo[1,2-a]pyridin-2-amine
Brand: ChemScene
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CAS No. 1350738-82-7
Cat. No. CS-0056792
Purity≥98%
MDL No.MFCD20502277

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5-Bromoimidazo[1,2-a]pyridin-2-amine|CS-0056792

Structure of 1350738-82-7

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General Information

CAS No. 1350738-82-7
Cat. No. CS-0056792
Purity ≥98%
MDL No. MFCD20502277
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆BrN₃
Molecular Weight 212.05
Synonym(s) None
SMILES NC1=CN2C(Br)=CC=CC2=N1

Description

5-Bromoimidazo[1,2-a]pyridin-2-amine features a fused heterocyclic core with a bromine atom at the 5-position and an amine group at the 2-position, enabling direct functionalization in cross-coupling reactions. This electron-deficient scaffold integrates readily into bioactive molecules, offering high reactivity and stability under standard conditions.

Application

5-Bromoimidazo[1,2-a]pyridin-2-amine serves as a versatile building block for heterocyclic synthesis, enabling efficient access to imidazo[1,2-a]pyridine-based scaffolds prevalent in medicinal chemistry. Its bromine substituent facilitates palladium-catalyzed cross-coupling reactions, while the amine functionality supports derivatization via acylation, alkylation, or coupling protocols. The compound exhibits good bench stability and is readily purified by chromatography, making it well-suited for iterative synthesis campaigns in API development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 43.32
LogP 1.679
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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5-Bromoimidazo[1,2-a]pyridin-2-amine

CAS No. 1350738-82-7

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