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CS-W001157 4
Total: USD 88.00

2-Benzoylthiophene

  • CAS No. 135-00-2

  • Cat. No. CS-0065515
  • Purity≥98%
  • MDL No.MFCD00022495

*For research and further manufacturing use only, not for direct human use.

2-Benzoylthiophene|CS-0065515

Structure of 135-00-2

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General Information

  • CAS No. 135-00-2
  • Cat. No. CS-0065515
  • Purity ≥98%
  • MDL No. MFCD00022495
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₈OS
  • Molecular Weight 188.25
  • Synonym(s) None
  • SMILES O=C(C1=CC=CS1)C2=CC=CC=C2

Description

2-Benzoylthiophene features a thiophene core fused with a benzoyl group, delivering enhanced electron-withdrawing character and structural rigidity. This configuration supports its utility in constructing functionalized heterocycles and advanced materials. The compound exhibits robust stability under standard conditions and facilitates efficient coupling reactions in synthetic pathways.

Application

2-Benzoylthiophene serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted thiophene derivatives through standard electrophilic substitution and coupling reactions. Its benzoyl group enhances stability and facilitates purification, while maintaining compatibility with common functional groups. This compound functions effectively in transition-metal-catalyzed transformations and provides a reliable scaffold for advanced synthetic applications in medicinal chemistry and materials science.

Synthesis

  • Route1
    • null|null
      6165-68-0
    • null|null
      98-88-4
    • ~95%
    • In-stock
      2-Benzoylthiophene|CS-0065515
      135-00-2

    References

    • Journal of Organic Chemistry, , vol. 71, # 15 p. 5725 - 5731
  • Route2
    • null|null
      6165-68-0
    • In-stock
      Benzoic anhydride|CS-0017826
      93-97-0
    • ~96%
    • In-stock
      2-Benzoylthiophene|CS-0065515
      135-00-2

    References

    • Journal of Organic Chemistry, , vol. 71, # 15 p. 5725 - 5731
  • Route3
    • null|null
      5271-67-0
    • In-stock
      Phenylboronic acid|CS-W001090
      98-80-6
    • ~83%
    • In-stock
      2-Benzoylthiophene|CS-0065515
      135-00-2

    References

    • Synlett, , # 15 art. no. U19305ST, p. 2309 - 2312

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.9791
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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