FMoc-N-me-d-cys(trt)-oh

Name: FMoc-N-me-d-cys(trt)-oh
Brand: ChemScene
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CAS No. 1349807-46-0
Cat. No. CS-0188099
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 1349807-46-0
Cat. No. CS-0188099
Purity ≥95%
MDL No. None
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₈H₃₃NO₄S
Molecular Weight 599.74
Synonym(s) S-Trityl Fmoc-D-N-Methyl-cysteine
SMILES CN([C@H](CSC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O)C(=O)OCC4C5=CC=CC=C5C6=CC=CC=C64

Description

FMoc-N-me-d-cys(trt)-OH features a protected d-cysteine residue with a trifluoromethylcarbamoyl (trt) side chain and an N-methylated amine, enabling stable incorporation into peptide chains. This configuration enhances backbone rigidity and resistance to enzymatic degradation, making it ideal for synthesizing bioactive peptides under standard conditions.

Application

FMoc-N-me-D-Cys(Trt)-OH serves as a robust building block for peptide synthesis, enabling site-specific incorporation of D-cysteine derivatives with orthogonal protection. The FMoc group allows for efficient N-terminal deprotection under mild basic conditions, while the Trt (trityl) side chain protection ensures high fidelity during coupling and minimizes disulfide scrambling. This derivative exhibits excellent bench stability, facilitates straightforward purification, and supports reliable access to cysteine-containing peptides and macrocyclic scaffolds in medicinal chemistry and biologics development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 66.84
LogP 8.0458
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 10

Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Functional Group Thioether

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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FMoc-N-me-d-cys(trt)-oh

CAS No. 1349807-46-0

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