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CS-W001157 4
Total: USD 88.00

1-(2,3-Dihydroxyphenyl)ethanone

  • CAS No. 13494-10-5

  • Cat. No. CS-0155145
  • Purity≥97%
  • MDL No.MFCD03424392

*For research and further manufacturing use only, not for direct human use.

1-(2,3-Dihydroxyphenyl)ethanone|CS-0155145

Structure of 13494-10-5

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General Information

  • CAS No. 13494-10-5
  • Cat. No. CS-0155145
  • Purity ≥97%
  • MDL No. MFCD03424392
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈O₃
  • Molecular Weight 152.15
  • Synonym(s) 2',3'-Dihydroxyacetophenone
  • SMILES CC(=O)C1=C(C(=CC=C1)O)O

Description

This phenolic ketone features two adjacent hydroxyl groups on the aromatic ring, enhancing solubility and enabling facile derivatization. The acetyl functionality provides a reactive handle for conjugation or further functionalization in synthetic pathways. Stable under standard bench conditions, it serves as a key intermediate in bioactive molecule synthesis.

Application

1-(2,3-Dihydroxyphenyl)ethanone serves as a versatile building block for catechol-containing scaffolds, enabling efficient synthesis of bioactive molecules through established coupling and oxidation protocols. Its ortho-dihydroxy functionality supports metal chelation and facilitates downstream functionalization, while the ketone group offers direct access to enantioselective transformations. Bench-stable and compatible with standard purification methods, it functions reliably in medicinal chemistry campaigns requiring phenolic motifs.

Synthesis

  • Route1

    References

    • Wu; Cole; Davidson; Dailey; Doring; Fedorchuk; Loch III; Thomas; Blosser; Borrelli; Kinsolving; Parker; Strand; Watkins Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 183 - 192
  • Route2
    • null|null
      120-80-9
    • null|null
      64-19-7
    • ~82%
    • In-stock
      1-(2,3-Dihydroxyphenyl)ethanone|CS-0155145
      13494-10-5

    References

    • Naeimi, Hossein; Moradi, Leila Bulletin of the Chemical Society of Japan, 2005 , vol. 78, # 2 p. 284 - 287
  • Route3

    References

    • Kagawa, Hitoshi; Shigematsu, Asako; Ohta, Shigeru; Harigaya, Yoshihiro Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 5 p. 547 - 554

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   1.3004
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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