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CS-W001157 4
Total: USD 88.00

1-(2-Hydroxy-3-methoxyphenyl)ethanone

  • CAS No. 703-98-0

  • Cat. No. CS-0046269
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(2-Hydroxy-3-methoxyphenyl)ethanone|CS-0046269

Structure of 703-98-0

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General Information

  • CAS No. 703-98-0
  • Cat. No. CS-0046269
  • Purity ≥98%
  • MDL No. None
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O₃
  • Molecular Weight 166.17
  • Synonym(s) Nsc 46634
  • SMILES CC(C1=CC=CC(OC)=C1O)=O

Description

This hydroxy-methoxyacetophenone features a strategically positioned phenolic hydroxyl and methoxy group that enhance solubility and reactivity in polar media. The ortho-hydroxyl enables intramolecular hydrogen bonding, stabilizing reactive intermediates during synthetic transformations. Its bench-stable nature supports reliable use in multistep organic synthesis and natural product derivatization.

Application

1-(2-Hydroxy-3-methoxyphenyl)ethanone serves as a versatile building block in synthetic organic chemistry, enabling efficient access to bioactive phenolic ketones and heterocyclic scaffolds. Its ortho-hydroxyl and meta-methoxy functionalities provide orthogonal reactivity for coupling, derivatization, and metal complexation. The compound exhibits bench stability, moderate solubility in common organic solvents, and facilitates straightforward purification via recrystallization or chromatography—making it well-suited for medicinal chemistry campaigns and natural product synthesis.

Synthesis

  • Route1

    References

    • Du, Zhen-Ting; Lu, Jing; Yu, Hong-Rui; Xu, Yan; Li, An-Pai Journal of Chemical Research, 2010 , # 4 p. 222 - 227
  • Route2

    References

    • Journal of Organic Chemistry, , vol. 70, # 18 p. 7290 - 7296
  • Route3
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      7169-06-4
    • ~%
    • In-stock
      1-(2-Hydroxy-3-methoxyphenyl)ethanone|CS-0046269
      703-98-0

    References

    • Journal of the American Chemical Society, , vol. 77, p. 2894

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   1.6034
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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