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CS-W001157 4
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3-Bromo-5H-pyrrolo[3,4-b]pyridin-7(6H)-one

  • CAS No. 1346809-61-7

  • Cat. No. CS-W000482
  • Purity≥97%
  • MDL No.MFCD20257894

*For research and further manufacturing use only, not for direct human use.

3-Bromo-5H-pyrrolo[3,4-b]pyridin-7(6H)-one|CS-W000482

Structure of 1346809-61-7

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General Information

  • CAS No. 1346809-61-7
  • Cat. No. CS-W000482
  • Purity ≥97%
  • MDL No. MFCD20257894
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrN₂O
  • Molecular Weight 213.03
  • Synonym(s) 3-bromo-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one
  • SMILES BrC1=CN=C2C(CNC2=O)=C1

Description

3-Bromo-5H-pyrrolo[3,4-b]pyridin-7(6H)-one is a heterocyclic building block featuring a brominated pyrrolopyridinone core. This scaffold delivers a reactive handle for cross-coupling reactions while maintaining stability under standard bench conditions. The molecule integrates readily into complex architectures due to its planar, electron-deficient framework and compatibility with palladium-mediated transformations.

Application

3-Bromo-5H-pyrrolo[3,4-b]pyridin-7(6H)-one serves as a versatile heterocyclic building block for medicinal chemistry and materials science applications. The bromine substituent enables efficient Pd-catalyzed cross-coupling reactions, while the lactam functionality offers hydrogen bonding capacity and structural rigidity. Its bench-stable nature and compatibility with diverse reaction conditions facilitate straightforward functionalization in multistep syntheses.

Synthesis

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      3-Bromo-5H-pyrrolo[3,4-b]pyridin-7(6H)-one|CS-W000482
      1346809-61-7

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED; FORD, Rhonan; KINCHIN, Elizabeth; MATHER, Andrew; METE, Antonio; MILLICHIP, Ian; STANIER, Andrew Geoffrey Patent: WO2011/154677 A1, 2011 ; Location in patent: Page/Page column 107 ; WO 2011/154677 A1
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    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED; FORD, Rhonan; KINCHIN, Elizabeth; MATHER, Andrew; METE, Antonio; MILLICHIP, Ian; STANIER, Andrew Geoffrey Patent: WO2011/154677 A1, 2011 ; WO 2011/154677 A1
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    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED; FORD, Rhonan; KINCHIN, Elizabeth; MATHER, Andrew; METE, Antonio; MILLICHIP, Ian; STANIER, Andrew Geoffrey Patent: WO2011/154677 A1, 2011 ; WO 2011/154677 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.99
  • LogP   1.0875
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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