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3,6-Dibromo-4,5-difluorobenzene-1,2-diamine

  • CAS No. 1345627-73-7

  • Cat. No. CS-0110734
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3,6-Dibromo-4,5-difluorobenzene-1,2-diamine|CS-0110734

Structure of 1345627-73-7

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General Information

  • CAS No. 1345627-73-7
  • Cat. No. CS-0110734
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄Br₂F₂N₂
  • Molecular Weight 301.91
  • Synonym(s) JACS-1345627-73-7
  • SMILES NC1=C(C(F)=C(C(Br)=C1N)F)Br

Description

3,6-Dibromo-4,5-difluorobenzene-1,2-diamine features a highly functionalized aromatic core with bromo and fluoro substituents flanking two diamino groups, enabling precise coupling in cross-coupling cascades. The electron-deficient ring enhances reactivity in Pd-catalyzed transformations, while the diamine motif offers dual coordination sites for metal complexation. This scaffold delivers structural rigidity and tunable electronic properties for advanced materials synthesis.

Application

3,6-Dibromo-4,5-difluorobenzene-1,2-diamine serves as a versatile building block for the synthesis of fluorinated heterocycles and functionalized aromatic scaffolds. The diamine functionality enables efficient coupling reactions, while the bromo and fluoro substituents offer orthogonal reactivity for late-stage diversification via palladium-catalyzed transformations. Its bench-stable nature and compatibility with standard cross-coupling protocols make it well-suited for medicinal chemistry and materials science applications requiring precise substitution patterns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   52.04
  • LogP   2.6542
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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