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CS-W001157 4
Total: USD 88.00

3,5-Dichlorobenzene-1,2-diamine

  • CAS No. 5233-04-5

  • Cat. No. CS-0157716
  • Purity≥97%
  • MDL No.MFCD00628987

*For research and further manufacturing use only, not for direct human use.

3,5-Dichlorobenzene-1,2-diamine|CS-0157716

Structure of 5233-04-5

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General Information

  • CAS No. 5233-04-5
  • Cat. No. CS-0157716
  • Purity ≥97%
  • MDL No. MFCD00628987
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆Cl₂N₂
  • Molecular Weight 177.03
  • Synonym(s) None
  • SMILES C1=C(C=C(C(=C1Cl)N)N)Cl

Description

3,5-Dichlorobenzene-1,2-diamine delivers a highly reactive diamine scaffold with two chlorine substituents positioned ortho to the amino groups. This arrangement enables selective coupling reactions in heterocyclic synthesis and facilitates incorporation into functional polymers. The electron-withdrawing chlorines enhance stability under standard conditions while maintaining nucleophilicity at the amine centers.

Application

3,5-Dichlorobenzene-1,2-diamine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling the construction of heterocyclic scaffolds via cyclization reactions. Its ortho-diamine functionality facilitates metal-catalyzed couplings and condensation processes, while the electron-withdrawing dichloro substituents enhance reactivity in electrophilic substitution. The compound exhibits good bench stability and is readily purified by recrystallization, supporting its use in scalable synthetic routes.

Synthesis

  • Route1

    References

    • Louvet, P.; Lallement, G.; Pernot-Marino, I.; Luu-Duc, C.; Blanchet, G. European Journal of Medicinal Chemistry, 1993 , vol. 28, # 1 p. 71 - 75
  • Route2

    References

    • Witt Chemische Berichte, 1874 , vol. 7, p. 1601 Chemische Berichte, 1875 , vol. 8, p. 1226
  • Route3
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    • In-stock
      3,5-Dichlorobenzene-1,2-diamine|CS-0157716
      5233-04-5

    References

    • Witt Chemische Berichte, 1874 , vol. 7, p. 1601 Chemische Berichte, 1875 , vol. 8, p. 1226

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.04
  • LogP   2.1578
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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