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CS-W001157 4
Total: USD 88.00

NOTA-NHS ester

  • CAS No. 1338231-09-6

  • Cat. No. CS-0128090
  • Molecule weight400.38
  • Purity≥90%
  • MDL No.MFCD30747764

*For research and further manufacturing use only, not for direct human use.

NOTA-NHS ester|CS-0128090

Structure of 1338231-09-6

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General Information

  • CAS No. 1338231-09-6
  • Cat. No. CS-0128090
  • Purity ≥90%
  • MDL No. MFCD30747764
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₄N₄O₈
  • Molecular Weight 400.38
  • Synonym(s) None
  • SMILES O=C(O)CN1CCN(CC(ON2C(CCC2=O)=O)=O)CCN(CC(O)=O)CC1

Application

NOTA-NHS ester serves as a versatile bifunctional linker for conjugating chelating agents to biomolecules. The NHS ester moiety readily reacts with primary amines under physiological conditions, enabling efficient protein or antibody labeling. The resulting amide bond provides stable attachment, while the NOTA core offers high-affinity binding for trivalent metal ions such as Ga³⁺ and Lu³⁺, making it ideal for radiolabeling applications in diagnostics and therapeutics.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   148
  • LogP   -2.3176
  • H_Acceptors   9
  • H_Donors   2
  • Rotatable_Bonds   7

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