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6-Bromo-7-fluoro-2,3-dihydro-1H-indole-2,3-dione

  • CAS No. 1336963-95-1

  • Cat. No. CS-0050255
  • Purity≥93%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Bromo-7-fluoro-2,3-dihydro-1H-indole-2,3-dione|CS-0050255

Structure of 1336963-95-1

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General Information

  • CAS No. 1336963-95-1
  • Cat. No. CS-0050255
  • Purity ≥93%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₃BrFNO₂
  • Molecular Weight 244.02
  • Synonym(s) 6-bromo-7-fluoroisatin
  • SMILES FC1=C(Br)C=CC2=C1NC(=O)C2=O

Description

6-Bromo-7-fluoro-2,3-dihydro-1H-indole-2,3-dione features a sterically constrained indole-2,3-dione core bearing bromo and fluoro substituents at the 6- and 7-positions, respectively. This electron-deficient scaffold enables direct functionalization in cross-coupling reactions and serves as a key building block for bioactive heterocycles in medicinal chemistry.

Application

6-Bromo-7-fluoro-2,3-dihydro-1H-indole-2,3-dione serves as a versatile building block in the synthesis of substituted indoles and heterocyclic scaffolds. Its electrophilic bromo and fluoro substituents enable regioselective coupling reactions, including Pd-catalyzed cross-couplings and nucleophilic aromatic substitutions. The dihydroindolone core offers functional group tolerance and bench stability, facilitating purification and integration into multi-step syntheses for medicinal chemistry and materials applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   46.17
  • LogP   1.723
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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