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CS-W001157 4
Total: USD 88.00

1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrazole

  • CAS No. 133560-57-3

  • Cat. No. CS-0036065
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrazole|CS-0036065

Structure of 133560-57-3

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General Information

  • CAS No. 133560-57-3
  • Cat. No. CS-0036065
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₈N₂OSi
  • Molecular Weight 198.34
  • Synonym(s) 1-SEM-1H-pyrazole
  • SMILES C[Si](C)(C)CCOCN1C=CC=N1

Description

This silyl-protected pyrazole derivative features a (2-trimethylsilyl)ethoxymethyl group that enables stable, orthogonal protection in synthetic sequences. The pendant trimethylsilyl moiety enhances solubility and facilitates selective deprotection under mild conditions, making it ideal for complex heterocyclic synthesis.

Application

1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrazole serves as a robust, bench-stable protecting group for primary amines and alcohols in complex molecule synthesis. Its silyl ether functionality enables selective deprotection under mild conditions, facilitating efficient orthogonal protection strategies. The pyrazole core provides enhanced stability and compatibility with diverse reaction environments, making it particularly useful in medicinal chemistry and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P403-P405-P501

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Computational Chemistry Data

  • TPSA   27.05
  • LogP   2.1954
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   5

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