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Fmoc-HomoGlu(OAll)-OH

  • CAS No. 133464-45-6

  • Cat. No. CS-0439227
  • Purity≥96%
  • MDL No.MFCD34182099

*For research and further manufacturing use only, not for direct human use.

Fmoc-HomoGlu(OAll)-OH|CS-0439227

Structure of 133464-45-6

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General Information

  • CAS No. 133464-45-6
  • Cat. No. CS-0439227
  • Purity ≥96%
  • MDL No. MFCD34182099
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₄H₂₅NO₆
  • Molecular Weight 423.46
  • Synonym(s) None
  • SMILES C(OC(N[C@@H](CCCC(OCC=C)=O)C(O)=O)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2

Description

Fmoc-HomoGlu(OAll)-OH is a protected amino acid derivative featuring a C-terminal allyl ester, enabling orthogonal deprotection in peptide synthesis. The Fmoc group ensures efficient stepwise chain elongation, while the allyl moiety offers stable storage and selective removal under mild conditions. This combination supports high-yield coupling and simplifies purification in complex sequence assembly.

Application

Fmoc-HomoGlu(OAll)-OH serves as a versatile building block for peptide synthesis, enabling the incorporation of homoglutamic acid with orthogonal protection. The Fmoc group ensures efficient stepwise chain elongation, while the allyl (OAll) ester provides stable, cleavable protection under mild conditions. This combination facilitates selective deprotection and functionalization, making it ideal for constructing complex peptide architectures, including those requiring post-synthetic modifications or conjugation strategies.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   101.93
  • LogP   3.8778
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   10

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