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CS-W001157 4
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2,2-Difluoroacetohydrazide

  • CAS No. 84452-98-2

  • Cat. No. CS-0523673
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,2-Difluoroacetohydrazide|CS-0523673

Structure of 84452-98-2

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General Information

  • CAS No. 84452-98-2
  • Cat. No. CS-0523673
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂H₄F₂N₂O
  • Molecular Weight 110.06
  • Synonym(s) difluoro-acetic acid hydrazine
  • SMILES O=C(NN)C(F)F

Description

2,2-Difluoroacetohydrazide features a highly polarized carbonyl group flanked by two fluorine atoms, enhancing electrophilicity for selective hydrazide coupling reactions. This bench-stable reagent integrates readily into bioconjugation workflows and serves as a key intermediate in the synthesis of fluorinated heterocycles and targeted therapeutics.

Application

2,2-Difluoroacetohydrazide serves as a versatile building block in synthetic organic chemistry, enabling the construction of fluorinated heterocycles and functionalized hydrazones. Its difluoromethyl group imparts enhanced metabolic stability and modulates electronic properties, facilitating downstream transformations such as cyclizations and nucleophilic additions. The compound exhibits excellent bench stability and compatibility with common reaction conditions, simplifying purification and integration into multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1325
Class : 4.1
Packing Group : Ⅱ
Hazard Statements : H228-H302-H315-H319-H335
Precautionary Statements : P210-P240-P241-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   -0.7586
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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