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CS-W001157 4
Total: USD 88.00

2,2-Difluoroacetohydrazide

  • CAS No. 84452-98-2

  • Cat. No. CS-0523673
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

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    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,2-Difluoroacetohydrazide|CS-0523673

Structure of 84452-98-2

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Description

2,2-Difluoroacetohydrazide features a highly polarized carbonyl group flanked by two fluorine atoms, enhancing electrophilicity for selective hydrazide coupling reactions. This bench-stable reagent integrates readily into bioconjugation workflows and serves as a key intermediate in the synthesis of fluorinated heterocycles and targeted therapeutics.

Application

2,2-Difluoroacetohydrazide serves as a versatile building block in synthetic organic chemistry, enabling the construction of fluorinated heterocycles and functionalized hydrazones. Its difluoromethyl group imparts enhanced metabolic stability and modulates electronic properties, facilitating downstream transformations such as cyclizations and nucleophilic additions. The compound exhibits excellent bench stability and compatibility with common reaction conditions, simplifying purification and integration into multi-step syntheses.

General Information

  • CAS No. 84452-98-2
  • Cat. No. CS-0523673
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂H₄F₂N₂O
  • Molecular Weight 110.06
  • Synonym(s) difluoro-acetic acid hydrazine
  • SMILES O=C(NN)C(F)F

Computational Chemistry Data

  • TPSA   55.12
  • LogP   -0.7586
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1325
Class : 4.1
Packing Group :
Hazard Statements : H228-H302-H315-H319-H335
Precautionary Statements : P210-P240-P241-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P405-P501

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