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Fmoc-Trp(Me)-OH

  • CAS No. 1334509-86-2

  • Cat. No. CS-0100992
  • Purity≥98%
  • MDL No.MFCD02684512

*For research and further manufacturing use only, not for direct human use.

Fmoc-Trp(Me)-OH|CS-0100992

Structure of 1334509-86-2

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General Information

  • CAS No. 1334509-86-2
  • Cat. No. CS-0100992
  • Purity ≥98%
  • MDL No. MFCD02684512
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₇H₂₄N₂O₄
  • Molecular Weight 440.49
  • Synonym(s) None
  • SMILES O=C(O)[C@H](CC1=CN(C)C2=C1C=CC=C2)NC(OCC3C4=C(C5=C3C=CC=C5)C=CC=C4)=O

Description

Fmoc-Trp(Me)-OH is a protected tryptophan derivative featuring a methoxy-substituted indole ring and an Fmoc group for orthogonal protection. This configuration enables efficient incorporation into peptide chains under standard coupling conditions, offering enhanced solubility and stability during solid-phase synthesis workflows.

Application

Fmoc-Trp(Me)-OH serves as a key building block in peptide synthesis, enabling the incorporation of methylated tryptophan residues with enhanced metabolic stability. The Fmoc group provides orthogonal protection for amine functionality, while the indole side chain remains intact for downstream modifications. This derivative exhibits excellent bench stability, compatibility with standard coupling protocols, and facilitates efficient purification via flash chromatography.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   80.56
  • LogP   4.7127
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   6

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