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CS-W001157 4
Total: USD 88.00

Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate

  • CAS No. 133046-46-5

  • Cat. No. CS-W006131
  • Purity≥97%
  • MDL No.MFCD10568298
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate|CS-W006131

Structure of 133046-46-5

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Description

Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate is a bench-stable, moisture-tolerant building block featuring a trifluoromethyl group that imparts strong electron-withdrawing character. This thiazole scaffold integrates readily into pharmaceutical intermediates and agrochemicals, where enhanced metabolic stability and lipophilicity are critical. The ester functionality enables straightforward derivatization under standard conditions.

Application

Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling efficient access to trifluoromethyl-substituted heterocycles. The molecule exhibits excellent bench stability and functional group tolerance, facilitating diverse transformations including nucleophilic substitution, palladium-catalyzed coupling reactions, and cyclization processes. Its electron-deficient thiazole core enhances reactivity in cross-coupling and conjugate addition protocols, making it a practical scaffold for the construction of bioactive molecules and advanced intermediates in API development.

General Information

  • CAS No. 133046-46-5
  • Cat. No. CS-W006131
  • Purity ≥97%
  • MDL No. MFCD10568298
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆F₃NO₂S
  • Molecular Weight 225.19
  • Synonym(s) 4-Thiazolecarboxylic acid, 2-(trifluoromethyl)-, ethyl ester
  • SMILES O=C(C1=CSC(C(F)(F)F)=N1)OCC

Computational Chemistry Data

  • TPSA   39.19
  • LogP   2.3386
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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