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Structure of 132997-77-4
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1-Chloro-6-methoxy-isoquinoline features a chlorine atom at the C1 position and a methoxy group at C6, creating a strategically positioned electrophilic site flanked by an electron-donating substituent. This electronic asymmetry enhances reactivity in palladium-catalyzed cross-coupling reactions while maintaining bench-stable handling properties. The molecule integrates readily into complex heterocyclic architectures under mild conditions.
1-Chloro-6-methoxy-isoquinoline serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-established reactivity at the C1 position. The methoxy group at C6 provides electronic modulation and enhances solubility, while the chloro substituent offers excellent functional group tolerance and bench stability. It functions reliably in Suzuki-Miyaura, Negishi, and Buchwald-Hartwig coupling protocols, facilitating efficient construction of complex isoquinoline-based scaffolds for drug discovery applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: