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tert-Butyl (2R)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate

  • CAS No. 132482-06-5

  • Cat. No. CS-0048661
  • Molecule weight215.29
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (2R)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate|CS-0048661

Structure of 132482-06-5

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General Information

  • CAS No. 132482-06-5
  • Cat. No. CS-0048661
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₁NO₃
  • Molecular Weight 215.29
  • Synonym(s) Boc-(R)-2-(pyrrolidin-2-yl)ethan-1-ol
  • SMILES CC(C)(C)OC(=O)N1CCC[C@@H]1CCO

Description

tert-Butyl (2R)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate features a chiral pyrrolidine core with a pendant hydroxyl-bearing side chain, enabling selective functionalization in asymmetric synthesis. This bench-stable, moisture-tolerant building block integrates readily into complex molecular architectures via standard coupling protocols.

Application

tert-Butyl (2R)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate serves as a versatile chiral building block for the synthesis of pyrrolidine-containing bioactive molecules. The pendant hydroxyl group enables efficient derivatization via esterification, etherification, or oxidation to aldehyde, while the tert-butyl carbamate protects the amine under standard reaction conditions. Its stereochemical integrity and bench stability facilitate reliable use in multi-step syntheses, particularly in medicinal chemistry and natural product elaboration.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H317
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   1.7683
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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