1-Phenyl-1H-pyrazole-5-carbaldehyde

Name: 1-Phenyl-1H-pyrazole-5-carbaldehyde
Brand: ChemScene
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CAS No. 132274-70-5
Cat. No. CS-0060550
Purity≥97%
MDL No.MFCD00103497

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-Phenyl-1H-pyrazole-5-carbaldehyde|CS-0060550

Structure of 132274-70-5

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General Information

CAS No. 132274-70-5
Cat. No. CS-0060550
Purity ≥97%
MDL No. MFCD00103497
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₈N₂O
Molecular Weight 172.18
Synonym(s) 1-phenyl-2H-pyrazole-5-carbaldehyde
SMILES O=CC1=CC=NN1C2=CC=CC=C2

Description

1-Phenyl-1H-pyrazole-5-carbaldehyde features a conjugated pyrazole core bearing a phenyl group and an aldehyde functionality at the 5-position. This electron-deficient carbonyl site enables efficient coupling in multicomponent reactions, while the aromatic framework enhances stability under standard bench conditions. The molecule integrates readily into heterocyclic scaffolds for medicinal chemistry applications.

Application

1-Phenyl-1H-pyrazole-5-carbaldehyde serves as a versatile building block in medicinal chemistry and heterocyclic synthesis. Its aldehyde functionality enables efficient imine formation, reductive amination, and coupling reactions with nucleophiles. The pyrazole core provides structural rigidity and favorable pharmacophoric properties, while the phenyl substituent enhances π-stacking potential. Bench-stable and readily purified by column chromatography, it facilitates scalable access to diverse substituted pyrazoles and fused heterocycles relevant to drug discovery programs.

Synthesis

Route1
- In-stock
  
  1126-00-7
- 68-12-2
- ~90%
- In-stock
  
  132274-70-5
References
- Schlaeger, Torsten; Schepmann, Dirk; Lehmkuhl, Kirstin; Holenz, Joerg; Vela, Jose Miguel; Buschmann, Helmut; Wuensch, Bernhard Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6704 - 6713

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 34.89
LogP 1.6848
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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1-Phenyl-1H-pyrazole-5-carbaldehyde

CAS No. 132274-70-5

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