(R)-Tetrahydro-2H-pyran-3-amine hydrochloride

Name: (R)-Tetrahydro-2H-pyran-3-amine hydrochloride
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CAS No. 1315500-31-2
Cat. No. CS-W006989
Purity≥96%
MDL No.MFCD09056863

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(R)-Tetrahydro-2H-pyran-3-amine hydrochloride|CS-W006989

Structure of 1315500-31-2

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General Information

CAS No. 1315500-31-2
Cat. No. CS-W006989
Purity ≥96%
MDL No. MFCD09056863
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₂ClNO
Molecular Weight 137.61
Synonym(s) (3R)-oxan-3-amine,hydrochloride
SMILES N[C@]1([H])CCCOC1.Cl

Description

(R)-Tetrahydro-2H-pyran-3-amine hydrochloride offers a stereochemically defined, bench-stable scaffold for asymmetric synthesis. The chiral amine moiety integrates readily into catalytic systems and peptide-like architectures, while the pyran ring provides conformational rigidity. This hydrochloride salt enhances solubility and handling under standard conditions.

Application

(R)-Tetrahydro-2H-pyran-3-amine hydrochloride serves as a chiral building block for medicinal chemistry and natural product synthesis, enabling stereoselective functionalization at the C3 position. Its bench-stable hydrochloride salt form facilitates handling and purification, while the secondary amine functionality supports diverse transformations including reductive amination, acylation, and coupling reactions. Functions effectively in the construction of tetrahydropyran-containing scaffolds prevalent in bioactive molecules.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 35.25
LogP 0.5459
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Tetrahydropyran compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-Tetrahydro-2H-pyran-3-amine hydrochloride

CAS No. 1315500-31-2

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