1-(4-Amino-3-chlorophenyl)cyclopropanecarboxylic acid

Name: 1-(4-Amino-3-chlorophenyl)cyclopropanecarboxylic acid
Brand: ChemScene
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CAS No. 1314738-42-5
Cat. No. CS-0161925
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-(4-Amino-3-chlorophenyl)cyclopropanecarboxylic acid|CS-0161925

Structure of 1314738-42-5

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Description

This cyclopropanecarboxylic acid derivative features a para-chloroaniline moiety linked via a cyclopropyl bridge, delivering enhanced metabolic stability and targeted bioactivity. The electron-rich aromatic ring enables efficient coupling in medicinal chemistry workflows, while the carboxylic acid group facilitates conjugation or salt formation. Bench-stable and moisture-tolerant, it serves as a key scaffold for kinase inhibitor development and peptide-based drug discovery.

Application

1-(4-Amino-3-chlorophenyl)cyclopropanecarboxylic acid serves as a versatile building block for medicinal chemistry campaigns, enabling direct incorporation into bioactive scaffolds via amide coupling or decarboxylation. The cyclopropane ring imparts conformational rigidity, while the amino and chloro substituents offer orthogonal handles for further functionalization. Bench-stable and readily purified by crystallization, it facilitates scalable synthesis of targeted compounds in drug discovery workflows.

General Information

CAS No. 1314738-42-5
Cat. No. CS-0161925
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₀ClNO₂
Molecular Weight 211.64
Synonym(s) None
SMILES O=C(C1(C2=CC=C(N)C(Cl)=C2)CC1)O

Computational Chemistry Data

TPSA 63.32
LogP 2.0384
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

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1-(4-Amino-3-chlorophenyl)cyclopropanecarboxylic acid

CAS No. 1314738-42-5

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