Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

8-Bromo-5,6-difluoro-2-methylquinoline

  • CAS No. 131190-82-4

  • Cat. No. CS-0172190
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

8-Bromo-5,6-difluoro-2-methylquinoline|CS-0172190

Structure of 131190-82-4

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 131190-82-4
  • Cat. No. CS-0172190
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₆BrF₂N
  • Molecular Weight 258.06
  • Synonym(s) 8-Bromo-5,6-difluoro-2-methyl-quinoline
  • SMILES CC1=NC2=C(C=C1)C(=C(C=C2Br)F)F

Description

8-Bromo-5,6-difluoro-2-methylquinoline features a sterically accessible quinoline core with strategically positioned halogen and methyl substituents. This electron-deficient scaffold enables efficient coupling in cross-coupling reactions and serves as a key building block in medicinal chemistry for targeted bioactive molecule synthesis.

Application

8-Bromo-5,6-difluoro-2-methylquinoline serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated heterocyclic scaffolds through palladium-catalyzed cross-coupling reactions. Its defined substitution pattern offers predictable regiochemistry and enhanced metabolic stability, while the bromo and difluoro functionalities provide orthogonal handles for further diversification. The compound exhibits good bench stability and is compatible with standard reaction conditions, facilitating efficient synthesis of complex molecular architectures.

Synthesis

  • Route1
    • null|null
      123-73-9
    • ~%
    • In-stock
      8-Bromo-5,6-difluoro-2-methylquinoline|CS-0172190
      131190-82-4

    References

    • WO2006/98912 A1, ; Page/Page column 55 ; WO 2006/098912 A1
  • Route2
    • In-stock
      N-(2-Bromo-4,5-difluorophenyl)acetamide|CS-0153976
      64695-81-4
    • null|null
      123-73-9
    • ~%
    • In-stock
      8-Bromo-5,6-difluoro-2-methylquinoline|CS-0172190
      131190-82-4

    References

    • Chemical and Pharmaceutical Bulletin, , vol. 44, # 4 p. 642 - 645

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.58392
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 8-Bromo-5,6-difluoro-2-methylquinoline sigma8-Bromo-5,6-difluoro-2-methylquinoline manufacturer8-Bromo-5,6-difluoro-2-methylquinoline price8-Bromo-5,6-difluoro-2-methylquinoline structure8-Bromo-5,6-difluoro-2-methylquinoline SDSbuy 8-Bromo-5,6-difluoro-2-methylquinoline8-Bromo-5,6-difluoro-2-methylquinoline supplier8-Bromo-5,6-difluoro-2-methylquinoline uses8-Bromo-5,6-difluoro-2-methylquinoline molecular weightprice of 8-Bromo-5,6-difluoro-2-methylquinoline8-Bromo-5,6-difluoro-2-methylquinoline chemical name formula of 8-Bromo-5,6-difluoro-2-methylquinoline
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label