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CS-W001157 4
Total: USD 88.00

(4-Bromo-3-(trifluoromethyl)phenyl)boronic acid

  • CAS No. 1310383-25-5

  • Cat. No. CS-0087983
  • Purity≥98%
  • MDL No.MFCD13181652

*For research and further manufacturing use only, not for direct human use.

(4-Bromo-3-(trifluoromethyl)phenyl)boronic acid|CS-0087983

Structure of 1310383-25-5

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General Information

  • CAS No. 1310383-25-5
  • Cat. No. CS-0087983
  • Purity ≥98%
  • MDL No. MFCD13181652
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BBrF₃O₂
  • Molecular Weight 268.82
  • Synonym(s) 4-Bromo-3-(trifluoromethyl)phenylboronic acid
  • SMILES OB(C1=CC=C(Br)C(C(F)(F)F)=C1)O

Description

This boronic acid features a trifluoromethyl group flanking a brominated aromatic ring, enabling efficient cross-coupling under standard conditions. The electron-deficient aryl moiety enhances reactivity in Suzuki-Miyaura processes, while the bench-stable boronate functionality simplifies handling and integration into complex molecular architectures.

Application

(4-Bromo-3-(trifluoromethyl)phenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation with aryl, vinyl, and heteroaryl halides. The trifluoromethyl group enhances metabolic stability and lipophilicity, making it valuable for medicinal chemistry applications. Bench-stable and readily purified by recrystallization, it functions reliably in standard coupling protocols across diverse reaction conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   1.1477
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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