Fmoc-D-allo-Thr-OH

Name: Fmoc-D-allo-Thr-OH
Brand: ChemScene
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CAS No. 130674-54-3
Cat. No. CS-0655405
Purity≥98%
MDL No.MFCD01318738

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 130674-54-3

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General Information

CAS No. 130674-54-3
Cat. No. CS-0655405
Purity ≥98%
MDL No. MFCD01318738
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₉H₁₉NO₅
Molecular Weight 341.36
Synonym(s) None
SMILES C[C@@H](O)[C@H](C(O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O

Description

Fmoc-D-allo-Thr-OH is a stereochemically defined amino acid derivative featuring a fluorenylmethoxy carbonyl (Fmoc) protecting group on the α-amino terminus and a hydroxyl-bearing side chain in the D-allo-threonine configuration. This configuration imparts distinct conformational rigidity and enhanced resistance to racemization during peptide synthesis. The molecule integrates readily into solid-phase workflows, where its bench-stable nature and predictable coupling kinetics streamline sequence assembly. Its polar side chain supports solubility in common organic solvents, facilitating handling under standard conditions.

Application

Fmoc-D-allo-Thr-OH serves as a key building block in peptide synthesis, enabling the incorporation of D-allo-threonine residues with high stereochemical fidelity. The Fmoc group provides orthogonal protection for the α-amino function, facilitating efficient stepwise chain elongation. The hydroxyl-bearing side chain offers controlled reactivity for selective derivatization and is compatible with standard coupling conditions, purification workflows, and bench-stable handling in solid-phase peptide synthesis.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

TPSA 95.86
LogP 2.3591
H_Acceptors 4
H_Donors 3
Rotatable_Bonds 5

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Threonine and derivatives

Building Blocks Functional Group Fmoc

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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Fmoc-D-allo-Thr-OH

CAS No. 130674-54-3

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