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CS-W001157 4
Total: USD 88.00

4-Methoxy-1-methyl-1H-indazol-3-amine

  • CAS No. 1305711-34-5

  • Cat. No. CS-0103498
  • Purity≥98%
  • MDL No.MFCD13176793

*For research and further manufacturing use only, not for direct human use.

4-Methoxy-1-methyl-1H-indazol-3-amine|CS-0103498

Structure of 1305711-34-5

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General Information

  • CAS No. 1305711-34-5
  • Cat. No. CS-0103498
  • Purity ≥98%
  • MDL No. MFCD13176793
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁N₃O
  • Molecular Weight 177.20
  • Synonym(s) None
  • SMILES NC1=NN(C)C2=C1C(OC)=CC=C2

Description

4-Methoxy-1-methyl-1H-indazol-3-amine features a fused bicyclic indazole core bearing a methoxy group at the 4-position and a methylamino substituent at the 3-position. This electron-rich scaffold integrates readily into kinase inhibitor scaffolds and offers enhanced solubility compared to analogs lacking polar functionalities.

Application

4-Methoxy-1-methyl-1H-indazol-3-amine serves as a versatile building block for medicinal chemistry and heterocyclic synthesis. Its structure features a substituted indazole core with orthogonal functional groups enabling direct coupling reactions, including Pd-catalyzed cross-couplings and amide bond formations. The methoxy and methyl substituents enhance solubility and metabolic stability, while the primary amine facilitates derivatization. This compound demonstrates bench stability and ease of purification, making it well-suited for scalable synthesis of kinase inhibitors and other bioactive scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   53.07
  • LogP   1.1641
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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