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CS-W001157 4
Total: USD 88.00

2-Azaspiro[3.5]nonane hydrochloride

  • CAS No. 1303968-07-1

  • Cat. No. CS-0138596
  • Purity≥98%
  • MDL No.MFCD18914329

*For research and further manufacturing use only, not for direct human use.

2-Azaspiro[3.5]nonane hydrochloride|CS-0138596

Structure of 1303968-07-1

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General Information

  • CAS No. 1303968-07-1
  • Cat. No. CS-0138596
  • Purity ≥98%
  • MDL No. MFCD18914329
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆ClN
  • Molecular Weight 161.67
  • Synonym(s) 2-Aza-spiro3.5none hydrochloride
  • SMILES [H]Cl.C1NCC12CCCCC2

Description

2-Azaspiro[3.5]nonane hydrochloride is a rigid, bicyclic amine scaffold featuring a spiro-configured nitrogen atom at the bridgehead. This structural motif imparts enhanced conformational stability and favorable solubility in polar solvents. The hydrochloride salt form ensures excellent crystallinity and shelf stability under ambient conditions. It serves as a key building block in medicinal chemistry for probing bioactive conformations in target-directed ligands.

Application

2-Azaspiro[3.5]nonane hydrochloride serves as a conformationally constrained, nitrogen-containing heterocyclic scaffold widely employed in medicinal chemistry for its ability to stabilize bioactive conformations. The spirocyclic structure imparts rigidity, enhancing target selectivity and metabolic stability. As a readily accessible building block, it facilitates the synthesis of complex alkaloids and pharmaceutically relevant scaffolds through standard functionalization and coupling reactions. Its salt form ensures improved solubility and handling in aqueous-based reaction systems.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.9619
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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