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L-Homophenylalanine tert-Butyl Ester Hydrochloride

  • CAS No. 130316-46-0

  • Cat. No. CS-0154859
  • Molecule weight271.78
  • Purity≥97%
  • MDL No.MFCD09029247

*For research and further manufacturing use only, not for direct human use.

L-Homophenylalanine tert-Butyl Ester Hydrochloride|CS-0154859

Structure of 130316-46-0

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General Information

  • CAS No. 130316-46-0
  • Cat. No. CS-0154859
  • Purity ≥97%
  • MDL No. MFCD09029247
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₂ClNO₂
  • Molecular Weight 271.78
  • Synonym(s) L-HOMOPHENYLALANINETERT-BUTYLESTERHYDROCHLORIDE
  • SMILES CC(C)(C)OC(=O)[C@H](CCC1=CC=CC=C1)N.Cl

Description

L-Homophenylalanine tert-Butyl Ester Hydrochloride features a protected amino acid backbone with enhanced solubility and stability under standard conditions. The tert-butyl ester group enables efficient incorporation into peptide chains, while the hydrochloride salt ensures reliable handling and storage. This derivative serves as a key building block in the synthesis of bioactive peptides and pharmaceutical intermediates.

Application

L-Homophenylalanine tert-Butyl Ester Hydrochloride serves as a key chiral building block for peptide synthesis, enabling the incorporation of a phenylalanine-derived side chain with enhanced solubility and stability. The tert-butyl ester group provides excellent orthogonal protection for carboxylic acid functionalities, facilitating selective coupling reactions. Its hydrochloride salt form enhances crystallinity and handling, simplifying purification and storage. This compound functions reliably in standard solid-phase and solution-phase peptide methodologies.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   2.71
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   4

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