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CS-W001157 4
Total: USD 88.00

2-Aminomethyl-4-methylpyridine

  • CAS No. 129768-95-2

  • Cat. No. CS-0084608
  • Purity≥95%
  • MDL No.MFCD06213857

*For research and further manufacturing use only, not for direct human use.

2-Aminomethyl-4-methylpyridine|CS-0084608

Structure of 129768-95-2

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General Information

  • CAS No. 129768-95-2
  • Cat. No. CS-0084608
  • Purity ≥95%
  • MDL No. MFCD06213857
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂
  • Molecular Weight None
  • Synonym(s) (4-Methylpyridin-2-yl)methanamine
  • SMILES CC1=CC(CN)=NC=C1

Description

2-Aminomethyl-4-methylpyridine features a pyridine core functionalized with a methyl group at the 4-position and a primary amine-bearing methylene linker at the 2-position. This configuration enables efficient coordination in catalytic systems and facilitates incorporation into ligand frameworks for transition metal complexes, offering enhanced solubility and stability under standard reaction conditions.

Application

2-Aminomethyl-4-methylpyridine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based pharmacophores. Its ortho-aminoalkyl side chain facilitates direct functionalization and metal-catalyzed coupling reactions, while the methyl group enhances metabolic stability. The compound exhibits excellent bench stability and compatibility with common protecting group strategies, making it ideal for iterative synthesis workflows.

Synthesis

  • Route1

    References

    • US2008/194650 A1, ; Page/Page column 31 ; US 20080194650 A1

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   0.84872
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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