2,6-Dichloro-4-methylpyridin-3-amine

Name: 2,6-Dichloro-4-methylpyridin-3-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 129432-25-3
Cat. No. CS-0061274
Purity≥96%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,6-Dichloro-4-methylpyridin-3-amine|CS-0061274

Structure of 129432-25-3

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General Information

CAS No. 129432-25-3
Cat. No. CS-0061274
Purity ≥96%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₆Cl₂N₂
Molecular Weight 177.03
Synonym(s) 2,6-Dichloro-4-methyl-3-aminopyridine
SMILES CC1=CC(=NC(=C1N)Cl)Cl

Description

2,6-Dichloro-4-methylpyridin-3-amine features a pyridine core bearing two chlorine substituents at the 2 and 6 positions and a methyl group at the 4 position, creating a sterically hindered, electron-deficient heterocyclic scaffold. This configuration enables efficient coupling in cross-coupling reactions and supports incorporation into bioactive molecules requiring precise electronic tuning.

Application

2,6-Dichloro-4-methylpyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds. Its electron-deficient pyridine core facilitates nucleophilic substitution reactions, while the methyl and amine groups provide orthogonal handles for further functionalization. The compound exhibits good bench stability and compatibility with standard coupling protocols, making it well-suited for modular synthesis of kinase inhibitors and other bioactive heterocycles.

Synthesis

Route1
- In-stock
  
  38841-54-2
- ~89%
- In-stock
  
  129432-25-3
References
- Grozinger; Fuchs; Hargrave; Mauldin; Vitous; Campbell; Adams Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 1 p. 259 - 263
Route2
- In-stock
  
  875-35-4
- ~%
- In-stock
  
  129432-25-3
References
- Journal of Medicinal Chemistry, , vol. 38, # 24 p. 4830 - 4838

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 38.91
LogP 2.27902
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2,6-Dichloro-4-methylpyridin-3-amine

CAS No. 129432-25-3

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