6-Chloro-4-methylpyridin-3-amine

Name: 6-Chloro-4-methylpyridin-3-amine
Brand: ChemScene
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CAS No. 66909-38-4
Cat. No. CS-W003078
Purity≥97%
MDL No.MFCD03427661

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Chloro-4-methylpyridin-3-amine|CS-W003078

Structure of 66909-38-4

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General Information

CAS No. 66909-38-4
Cat. No. CS-W003078
Purity ≥97%
MDL No. MFCD03427661
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClN₂
Molecular Weight 142.59
Synonym(s) 5-Amino-2-chloro-4-methylpyridine
SMILES Clc1ncc(c(c1)C)N

Description

6-Chloro-4-methylpyridin-3-amine features a pyridine core functionalized with chlorine and methyl groups at the 6- and 4-positions, respectively, and an amine group at the 3-position. This electron-deficient heterocycle serves as a key scaffold in medicinal chemistry, enabling direct coupling reactions and facilitating incorporation into bioactive molecules through its reactive nitrogen site.

Application

6-Chloro-4-methylpyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds. Its chloro group facilitates nucleophilic substitution and palladium-catalyzed coupling reactions, while the amino and methyl functionalities provide orthogonal handles for further functionalization. The compound exhibits good bench stability and is readily purified by standard techniques, making it well-suited for iterative synthesis workflows in API development.

Synthesis

Route1
- In-stock
  
  23056-33-9
- ~77%
- In-stock
  
  66909-38-4
References
- Takeshita, Mitsuhiro; Yoshida, Sachiko Heterocycles, 1990 , vol. 31, # 12 p. 2201 - 2204

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 1759
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

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Computational Chemistry Data

TPSA 38.91
LogP 1.62562
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-4-methylpyridin-3-amine

CAS No. 66909-38-4

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