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CS-W001157 4
Total: USD 88.00

6-Chloro-1H-indazole-3-carboxylic acid

  • CAS No. 129295-31-4

  • Cat. No. CS-W022473
  • Purity≥98%
  • MDL No.MFCD05663998

*For research and further manufacturing use only, not for direct human use.

6-Chloro-1H-indazole-3-carboxylic acid|CS-W022473

Structure of 129295-31-4

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General Information

  • CAS No. 129295-31-4
  • Cat. No. CS-W022473
  • Purity ≥98%
  • MDL No. MFCD05663998
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClN₂O₂
  • Molecular Weight 196.59
  • Synonym(s) None
  • SMILES ClC1=CC=C2C(=C1)[NH]N=C2C(=O)O

Description

6-Chloro-1H-indazole-3-carboxylic acid features a chlorine atom at the 6-position of the indazole scaffold, enhancing electron-withdrawing character and metabolic stability. The carboxylic acid group at the 3-position enables direct conjugation or derivatization in medicinal chemistry campaigns. This rigid heterocyclic core integrates readily into bioactive molecules requiring targeted polarity and hydrogen-bonding capacity.

Application

6-Chloro-1H-indazole-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive scaffolds via amide coupling or Suzuki-Miyaura cross-coupling. The chloro group facilitates further functionalization, while the carboxylic acid enables derivatization under standard conditions. Its bench-stable crystalline form supports reliable handling and purification in synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   1.9145
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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