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Ethyl trans-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxycyclobutanecarboxylate

  • CAS No. 129288-14-8

  • Cat. No. CS-0135516
  • Molecule weight259.30
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Ethyl trans-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxycyclobutanecarboxylate|CS-0135516

Structure of 129288-14-8

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General Information

  • CAS No. 129288-14-8
  • Cat. No. CS-0135516
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₁NO₅
  • Molecular Weight 259.30
  • Synonym(s) None
  • SMILES O[C@@H]1C[C@@](C(OCC)=O)(NC(OC(C)(C)C)=O)C1

Description

Ethyl trans-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxycyclobutanecarboxylate features a sterically hindered tert-butoxycarbonyl-protected amino group and a hydroxyl-bearing cyclobutane core. This bench-stable scaffold enables direct incorporation into peptidomimetic syntheses, where the trans-configured ring system imparts conformational rigidity and enhances metabolic stability in bioactive molecule design.

Application

Ethyl trans-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxycyclobutanecarboxylate serves as a versatile chiral building block for the synthesis of bioactive cyclobutane-containing scaffolds. The protected amine and hydroxyl groups enable orthogonal functionalization, while the cyclobutane core provides conformational rigidity. Its bench-stable nature and compatibility with standard coupling and reduction protocols facilitate efficient access to complex heterocycles and potential pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   84.86
  • LogP   0.9677
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   3

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