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CS-W001157 4
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3-Bromo-5-chloro-2-isopropoxypyridine

  • CAS No. 1289133-38-5

  • Cat. No. CS-0194861
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromo-5-chloro-2-isopropoxypyridine|CS-0194861

Structure of 1289133-38-5

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General Information

  • CAS No. 1289133-38-5
  • Cat. No. CS-0194861
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉BrClNO
  • Molecular Weight 250.52
  • Synonym(s) None
  • SMILES CC(C)OC1=C(C=C(C=N1)Cl)Br

Description

3-Bromo-5-chloro-2-isopropoxypyridine is a halogenated pyridine derivative featuring orthogonal reactive sites for cross-coupling and functionalization. The isopropoxy group enhances solubility in organic media, while the bromo and chloro substituents enable selective metal-catalyzed transformations. This scaffold delivers high stability under standard conditions and supports efficient integration into complex heterocyclic architectures.

Application

3-Bromo-5-chloro-2-isopropoxypyridine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The isopropoxy group enhances solubility and stability, while the ortho-bromo and meta-chloro substituents allow for sequential functionalization. Its bench-stable nature and predictable regioselectivity facilitate efficient access to substituted pyridine scaffolds relevant to medicinal chemistry and agrochemical development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   3.2847
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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