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(5-(tert-Butyl)-2-methoxyphenyl)boronic acid

  • CAS No. 128733-85-7

  • Cat. No. CS-0154916
  • Purity≥95%
  • MDL No.MFCD06201034

*For research and further manufacturing use only, not for direct human use.

(5-(tert-Butyl)-2-methoxyphenyl)boronic acid|CS-0154916

Structure of 128733-85-7

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General Information

  • CAS No. 128733-85-7
  • Cat. No. CS-0154916
  • Purity ≥95%
  • MDL No. MFCD06201034
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₇BO₃
  • Molecular Weight 208.06
  • Synonym(s) 5-Tert-butyl-2-methoxyphenylboronic acid
  • SMILES CC(C)(C)C1=CC(=C(C=C1)OC)B(O)O

Description

This boronate moiety features a sterically hindered tert-butyl group and a methoxy substituent, enhancing stability and solubility. The para-methoxy functionality directs regioselective coupling in Suzuki-Miyaura reactions, enabling efficient access to complex aryl scaffolds under standard conditions.

Application

(5-(tert-Butyl)-2-methoxyphenyl)boronic acid serves as a robust building block for Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds under mild conditions. The tert-butyl and methoxy groups provide enhanced solubility and stability, while the boronic acid functionality offers high functional group tolerance and reliable coupling efficiency. This reagent facilitates the synthesis of complex aromatic systems commonly found in pharmaceutical intermediates and agrochemicals.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   0.6725
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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