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CS-W001157 4
Total: USD 88.00

2-(Aminooxy)ethanol

  • CAS No. 3279-95-6

  • Cat. No. CS-W011361
  • Purity≥95%
  • MDL No.MFCD00517034

*For research and further manufacturing use only, not for direct human use.

2-(Aminooxy)ethanol|CS-W011361

Structure of 3279-95-6

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General Information

  • CAS No. 3279-95-6
  • Cat. No. CS-W011361
  • Purity ≥95%
  • MDL No. MFCD00517034
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂H₇NO₂
  • Molecular Weight 77.08
  • Synonym(s) None
  • SMILES OCCON

Description

2-(Aminooxy)ethanol features a primary amine and hydroxyl group separated by an ethylene linker, enabling dual functionality in conjugation chemistry. This bifunctional scaffold facilitates site-specific labeling of carbonyl-containing biomolecules under mild conditions. The molecule exhibits excellent solubility in aqueous and polar organic solvents, supporting its use in biological and synthetic applications.

Application

2-(Aminooxy)ethanol serves as a versatile bifunctional building block, enabling efficient conjugation via oxime formation under mild conditions. Its primary amine and hydroxyl groups offer orthogonal reactivity, facilitating selective derivatization in peptide labeling, polymer functionalization, and bioconjugation workflows. The compound exhibits good bench stability and ease of purification, making it well-suited for routine synthetic applications in medicinal chemistry and materials science.

Synthesis

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    References

    • Dhanak, Dashyant; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2829 - 2832 Title/Abstract Full Text View citing articles Show Details Dhanak, Dashyant; Reese, Colin B.; Romana, Sergio; Zappia, Giovanni Journal of the Chemical Society, Chemical Communications, 1986 , # 12 p. 903 - 904
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      2-(Aminooxy)ethanol|CS-W011361
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    References

    • Nicolaus,B.J.R. et al. Helvetica Chimica Acta, 1962 , vol. 45, p. 358 - 370
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      2-(Aminooxy)ethanol|CS-W011361
      3279-95-6

    References

    • Schumann,E.L. et al. Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 464 - 477

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.48
  • LogP   -1.131
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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