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Structure of 1286734-84-6
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2-(Trifluoromethyl)thiazole-5-carboxylic acid features a trifluoromethyl group at the 2-position and a carboxylic acid at the 5-position of the thiazole ring, conferring strong electron-withdrawing character and enhanced metabolic stability. This scaffold integrates readily into bioactive molecules, particularly in medicinal chemistry applications targeting kinase inhibition and antimicrobial agents. The compound exhibits excellent solubility in polar aprotic solvents and maintains stability under standard bench conditions.
2-(Trifluoromethyl)thiazole-5-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling and functionalization reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the carboxylic acid facilitates direct derivatization or incorporation into peptide-like scaffolds. The molecule exhibits excellent bench stability and compatibility with common reaction conditions, making it ideal for iterative synthesis campaigns and API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: