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2-(Trifluoromethyl)thiazole-5-carbaldehyde

  • CAS No. 903130-38-1

  • Cat. No. CS-0113045
  • Molecule weight181.14
  • Purity≥95%
  • MDL No.MFCD08448192

*For research and further manufacturing use only, not for direct human use.

2-(Trifluoromethyl)thiazole-5-carbaldehyde|CS-0113045

Structure of 903130-38-1

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General Information

  • CAS No. 903130-38-1
  • Cat. No. CS-0113045
  • Purity ≥95%
  • MDL No. MFCD08448192
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂F₃NOS
  • Molecular Weight 181.14
  • Synonym(s) 5-Formyl-2-(trifluoromethyl)-1,3-thiazole
  • SMILES O=CC1=CN=C(C(F)(F)F)S1

Description

2-(Trifluoromethyl)thiazole-5-carbaldehyde features a trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the thiazole ring provides a rigid, polar scaffold. The aldehyde functionality enables direct coupling in multistep syntheses, particularly for bioactive heterocycles and pharmaceutical intermediates. This compound exhibits excellent bench-stability and compatibility with standard synthetic protocols.

Application

2-(Trifluoromethyl)thiazole-5-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds through standard coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the aldehyde functionality facilitates efficient derivatization via reductive amination, nucleophilic addition, or condensation reactions. Bench-stable and compatible with common protecting groups, it functions reliably in multi-step synthetic sequences for API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.9744
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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