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THP-PEG4-OH

  • CAS No. 128660-97-9

  • Cat. No. CS-0105845
  • Purity≥95%
  • MDL No.MFCD26127805

*For research and further manufacturing use only, not for direct human use.

THP-PEG4-OH|CS-0105845

Structure of 128660-97-9

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General Information

  • CAS No. 128660-97-9
  • Cat. No. CS-0105845
  • Purity ≥95%
  • MDL No. MFCD26127805
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₆O₆
  • Molecular Weight 278.34
  • Synonym(s) None
  • SMILES OCCOCCOCCOCCOC1CCCCO1

Description

THP-PEG4-OH is a bench-stable, moisture-tolerant protecting group for hydroxyl functionalities, featuring a tetrahydropyranyl moiety linked via a four-ethylene glycol spacer. This configuration enables selective protection in complex synthesis while offering facile deprotection under mild acidic conditions. The terminal primary alcohol facilitates conjugation and further derivatization in bioconjugation workflows.

Application

THP-PEG4-OH serves as a versatile, bench-stable protecting group for hydroxyl functionalities in complex molecule synthesis. Its tetrahydropyranyl (THP) moiety enables selective protection under mild acidic conditions, while the PEG4 linker provides enhanced solubility and compatibility with aqueous/organic media. The terminal OH group facilitates further functionalization or conjugation, making it ideal for modular assembly of peptide- and nucleotide-based constructs.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   66.38
  • LogP   0.5717
  • H_Acceptors   6
  • H_Donors   1
  • Rotatable_Bonds   12

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