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CS-W001157 4
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Tert-butyl n-[1-(aminomethyl)cyclobutyl]carbamate

  • CAS No. 1286330-22-0

  • Cat. No. CS-0233457
  • Molecule weight200.28
  • Purity≥97%
  • MDL No.MFCD13194722

*For research and further manufacturing use only, not for direct human use.

Tert-butyl n-[1-(aminomethyl)cyclobutyl]carbamate|CS-0233457

Structure of 1286330-22-0

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General Information

  • CAS No. 1286330-22-0
  • Cat. No. CS-0233457
  • Purity ≥97%
  • MDL No. MFCD13194722
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₀N₂O₂
  • Molecular Weight 200.28
  • Synonym(s) (1-Aminomethyl-cyclobutyl)-carbamic acid tert-butyl ester
  • SMILES CC(C)(OC(NC1(CN)CCC1)=O)C

Description

Tert-butyl n-[1-(aminomethyl)cyclobutyl]carbamate features a cyclobutyl scaffold bearing a primary amine and a tert-butyl carbamate protecting group, enabling selective derivatization. This stable, bench-ready building block integrates readily into peptide backbones and bioactive molecule synthesis, offering controlled reactivity under standard conditions.

Application

Tert-butyl N-[1-(aminomethyl)cyclobutyl]carbamate serves as a versatile building block for cyclobutyl-containing scaffolds in medicinal chemistry. The tert-butyl carbamate group provides stability and facilitates straightforward deprotection under mild acidic conditions. The primary amine functionality enables direct functionalization, including reductive amination and coupling reactions, while the cyclobutyl ring offers conformational rigidity useful in optimizing target binding affinity. This compound is bench-stable, easily purified by chromatography, and compatible with standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   64.35
  • LogP   1.3925
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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