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Structure of 128073-33-6
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This cyclopropanecarboxylic acid features a sterically constrained ring system with dual fluorine substituents at the geminal position, enhancing metabolic stability and lipophilicity. The methyl group at C1 introduces electronic modulation, while the carboxylic acid functionality enables direct coupling in peptide synthesis or derivatization for bioactive molecule design.
2,2-Difluoro-1-methylcyclopropanecarboxylic acid serves as a valuable building block in medicinal chemistry, enabling the introduction of a rigid, electron-deficient cyclopropane motif into bioactive molecules. Its difluoromethylcyclopropane core enhances metabolic stability and modulates lipophilicity, while the carboxylic acid functionality facilitates direct derivatization or salt formation. The compound exhibits good bench stability and compatibility with standard coupling reactions, making it suitable for use in peptide synthesis, macrocyclization, and scaffold diversification workflows.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H302-H314
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Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501
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Lot numbers can be found on the outside label of a product: