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CS-W001157 4
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4-Bromo-2-chloropyridine-3-carboxaldehyde

  • CAS No. 128071-84-1

  • Cat. No. CS-0139521
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-chloropyridine-3-carboxaldehyde|CS-0139521

Structure of 128071-84-1

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General Information

  • CAS No. 128071-84-1
  • Cat. No. CS-0139521
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClNO
  • Molecular Weight 220.45
  • Synonym(s) 4-Bromo-2-chloro-3-formylpyridine 4-Bromo-2-chloronicotinaldehyde
  • SMILES O=CC1=C(Br)C=CN=C1Cl

Description

4-Bromo-2-chloropyridine-3-carboxaldehyde delivers a reactive aldehyde group flanked by bromo and chloro substituents at electron-deficient positions on the pyridine ring. This configuration enables direct coupling in cross-coupling reactions, facilitating rapid access to complex heterocyclic architectures under mild conditions. The molecule exhibits high stability and compatibility with diverse reaction environments.

Application

4-Bromo-2-chloropyridine-3-carboxaldehyde serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling efficient construction of pyridine-based scaffolds. Its orthogonal halogen and aldehyde functionalities facilitate selective cross-coupling reactions and nucleophilic additions, offering high functional group tolerance and bench stability for downstream transformations.

Synthesis

  • Route1
    • In-stock
      3-Bromo-2-chlorolpyridine|CS-B1311
      52200-48-3
    • null|null
      68-12-2
    • ~%
    • In-stock
      4-Bromo-2-chloropyridine-3-carboxaldehyde|CS-0139521
      128071-84-1

    References

    • Journal of Organometallic Chemistry, , vol. 382, # 3 p. 319 - 332

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H319
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   2.31
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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