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CS-W001157 4
Total: USD 88.00

4-Bromo-6-chloropyridine-3-carbaldehyde

  • CAS No. 1060805-64-2

  • Cat. No. CS-0060142
  • Purity≥97%
  • MDL No.MFCD13189209

*For research and further manufacturing use only, not for direct human use.

4-Bromo-6-chloropyridine-3-carbaldehyde|CS-0060142

Structure of 1060805-64-2

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General Information

  • CAS No. 1060805-64-2
  • Cat. No. CS-0060142
  • Purity ≥97%
  • MDL No. MFCD13189209
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClNO
  • Molecular Weight 220.45
  • Synonym(s) 4-Bromo-6-chloronicotinaldehyde
  • SMILES C1=C(C(=CN=C1Cl)C=O)Br

Description

4-Bromo-6-chloropyridine-3-carbaldehyde features a pyridine core functionalized with bromo, chloro, and formyl groups at distinct positions, enabling selective coupling in cross-coupling and heterocyclic synthesis. The electron-deficient aromatic ring enhances reactivity in nucleophilic substitution, while the aldehyde group provides a handle for imine formation or derivatization. This compound serves as a key intermediate in pharmaceutical and agrochemical research.

Application

4-Bromo-6-chloropyridine-3-carbaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of halogenated pyridine scaffolds into target molecules. The aldehyde functionality facilitates nucleophilic additions, reductive aminations, and condensation reactions, while the bromo and chloro substituents support subsequent cross-coupling transformations such as Suzuki-Miyaura and Stille reactions. Bench-stable and compatible with standard purification methods, it functions effectively in multi-step syntheses requiring orthogonal reactivity.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   2.31
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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