1-Methyl-1H-pyrazol-4-amine hydrochloride

Name: 1-Methyl-1H-pyrazol-4-amine hydrochloride
Brand: ChemScene
Availability: InStock
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CAS No. 127107-23-7
Cat. No. CS-D1698
Purity≥97%
MDL No.MFCD07626616

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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1-Methyl-1H-pyrazol-4-amine hydrochloride|CS-D1698

Structure of 127107-23-7

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General Information

CAS No. 127107-23-7
Cat. No. CS-D1698
Purity ≥97%
MDL No. MFCD07626616
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₈ClN₃
Molecular Weight 133.58
Synonym(s) 1-Methyl-1H-pyrazol-4-amine hydrochloride; 4-AMino-1-Methylpyrazole Hydrochloride
SMILES NC1=CN(C)N=C1.[H]Cl

Description

1-Methyl-1H-pyrazol-4-amine hydrochloride features a pyrazole core with a methylated nitrogen and a primary amine at the 4-position, delivering enhanced solubility and stability under standard conditions. This bench-stable salt form facilitates direct incorporation into medicinal chemistry campaigns, serving as a key heterocyclic building block for kinase inhibitors and bioactive scaffolds.

Application

1-Methyl-1H-pyrazol-4-amine hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrazole-based scaffolds. Its well-defined reactivity facilitates direct functionalization at the 4-position and ortho-coupling with electrophiles. The hydrochloride salt enhances bench stability and solubility, simplifying handling and purification in standard synthetic workflows.

Synthesis

Route1
- In-stock
  
  69843-13-6
- ~%
- In-stock
  
  127107-23-7
References
- Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 1941 - 1946

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 43.84
LogP 0.4241
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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1-Methyl-1H-pyrazol-4-amine hydrochloride

CAS No. 127107-23-7

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