(S)-Fmoc-3-Fluoro-Tyrosine

Name: (S)-Fmoc-3-Fluoro-Tyrosine
Brand: ChemScene
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CAS No. 1270290-56-6
Cat. No. CS-0439210
Purity≥97%
MDL No.MFCD07783957

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 1270290-56-6
Cat. No. CS-0439210
Purity ≥97%
MDL No. MFCD07783957
Storage 4°C, stored under nitrogen, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₂₀FNO₅
Molecular Weight 421.42
Synonym(s) N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-fluoro-L-tyrosine
SMILES C(OC(N[C@@H](CC1=CC(F)=C(O)C=C1)C(O)=O)=O)C2C=3C(C=4C2=CC=CC4)=CC=CC3

Description

(S)-Fmoc-3-Fluoro-Tyrosine integrates a fluorinated tyrosine residue with enhanced metabolic stability and improved membrane permeability. The ortho-fluoro substitution modulates electronic properties, enabling precise control over peptide conformation and reactivity in synthetic biologics. This bench-stable derivative supports efficient solid-phase peptide synthesis and is compatible with standard deprotection protocols.

Application

(S)-Fmoc-3-Fluoro-Tyrosine serves as a valuable building block for the synthesis of peptide libraries and bioactive oligomers, enabling site-specific incorporation of a fluorinated tyrosine residue. The Fmoc group ensures orthogonal protection during solid-phase peptide synthesis, while the 3-fluoro substitution enhances metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with standard coupling protocols facilitate efficient, high-yield assembly in medicinal chemistry workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 95.86
LogP 4.0657
H_Acceptors 4
H_Donors 3
Rotatable_Bonds 6

Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Functional Group Phenol

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Key Words

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(S)-Fmoc-3-Fluoro-Tyrosine

CAS No. 1270290-56-6

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