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CS-W001157 4
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4-((tert-Butyldimethylsilyl)oxy)cyclohexanol

  • CAS No. 126931-29-1

  • Cat. No. CS-0154944
  • Purity≥96%
  • MDL No.MFCD13190776

*For research and further manufacturing use only, not for direct human use.

4-((tert-Butyldimethylsilyl)oxy)cyclohexanol|CS-0154944

Structure of 126931-29-1

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General Information

  • CAS No. 126931-29-1
  • Cat. No. CS-0154944
  • Purity ≥96%
  • MDL No. MFCD13190776
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₆O₂Si
  • Molecular Weight 230.42
  • Synonym(s) 4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexanol
  • SMILES CC(C)(C)[Si](C)(C)OC1CCC(CC1)O

Description

This silyl-protected cyclohexanol features a tert-butyldimethylsilyl ether group that confers enhanced stability and solubility in organic media. The protected hydroxyl group enables selective deprotection under mild acidic conditions, facilitating controlled functionalization in complex synthesis workflows.

Application

4-((tert-Butyldimethylsilyl)oxy)cyclohexanol serves as a stable, bench-ready protecting group for diol and polyol systems, enabling selective functionalization in complex molecule synthesis. The silyl ether functionality exhibits high thermal and chemical stability under standard reaction conditions, facilitates straightforward deprotection with fluoride sources, and tolerates a broad range of synthetic transformations including oxidation, reduction, and coupling reactions. Its use simplifies purification and enhances yield in multi-step sequences.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   3.3117
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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