2-Bromo-6-methoxypyridin-4-amine

Name: 2-Bromo-6-methoxypyridin-4-amine
Brand: ChemScene
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CAS No. 1196152-34-7
Cat. No. CS-0134134
Molecule weight203.04
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2-Bromo-6-methoxypyridin-4-amine|CS-0134134

Structure of 1196152-34-7

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General Information

CAS No. 1196152-34-7
Cat. No. CS-0134134
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇BrN₂O
Molecular Weight 203.04
Synonym(s) 2-Bromo-6-methoxy-4-aminopyridine
SMILES NC1=CC(Br)=NC(OC)=C1

Description

2-Bromo-6-methoxypyridin-4-amine features a pyridine core functionalized with bromo and methoxy groups at the 2- and 6-positions, respectively, and an amino group at the 4-position. This electron-deficient heterocycle enables direct coupling in cross-coupling reactions, serving as a key building block for bioactive molecules and agrochemical intermediates. The compound exhibits stability under standard conditions and facilitates efficient derivatization in medicinal chemistry workflows.

Application

2-Bromo-6-methoxypyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined electrophilic bromide and amine functionality. The methoxy group enhances solubility and modulates electronic properties, while the compound exhibits good bench stability and compatibility with standard protecting group strategies. It functions effectively in Suzuki-Miyaura, Buchwald-Hartwig, and other C–N/C–C bond-forming transformations for constructing complex heterocyclic scaffolds.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

TPSA 48.14
LogP 1.4349
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Bromo-6-methoxypyridin-4-amine

CAS No. 1196152-34-7

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