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CS-W001157 4
Total: USD 88.00

3-(3-Bromophenyl)piperidine-2,6-dione

  • CAS No. 1268142-04-6

  • Cat. No. CS-0928763
  • Purity≥98%
  • MDL No.MFCD19372738

*For research and further manufacturing use only, not for direct human use.

3-(3-Bromophenyl)piperidine-2,6-dione|CS-0928763

Structure of 1268142-04-6

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General Information

  • CAS No. 1268142-04-6
  • Cat. No. CS-0928763
  • Purity ≥98%
  • MDL No. MFCD19372738
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₀BrNO₂
  • Molecular Weight 268.11
  • Synonym(s) None
  • SMILES O=C1NC(=O)C(C=2C=CC=C(Br)C2)CC1

Description

3-(3-Bromophenyl)piperidine-2,6-dione features a brominated phenyl group attached to a piperidine-2,6-dione core, delivering enhanced electron-withdrawing character and structural rigidity. This scaffold serves as a high-value intermediate in medicinal chemistry campaigns targeting CNS modulators and kinase inhibitors. The bromine substituent enables further diversification via cross-coupling reactions, while the diketone framework supports chelation and conformational control. Bench-stable under standard conditions, it integrates efficiently into multi-step synthesis workflows.

Application

3-(3-Bromophenyl)piperidine-2,6-dione serves as a versatile building block for heterocyclic synthesis, enabling efficient access to substituted piperidinones and fused ring systems. Its brominated aryl group facilitates palladium-catalyzed coupling reactions, while the diketone functionality supports sequential functionalization and cyclization. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for iterative synthetic strategies in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.17
  • LogP   2.0817
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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