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CS-W001157 4
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5-Bromo-4-fluoro-2-iodo-aniline

  • CAS No. 1265236-37-0

  • Cat. No. CS-0310085
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-4-fluoro-2-iodo-aniline|CS-0310085

Structure of 1265236-37-0

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General Information

  • CAS No. 1265236-37-0
  • Cat. No. CS-0310085
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrFIN
  • Molecular Weight 315.91
  • Synonym(s) 5-Bromo-4-fluoro-2-iodoaniline
  • SMILES NC1=C(I)C=C(F)C(Br)=C1

Description

5-Bromo-4-fluoro-2-iodo-aniline features a trihalogenated aromatic core with distinct electronic and steric profiles. The ortho-iodo group enables efficient cross-coupling reactions, while the meta-bromo and para-fluoro substituents offer orthogonal reactivity handles. This molecule serves as a high-precision building block for complex heterocycles and functional materials under standard catalytic conditions.

Application

5-Bromo-4-fluoro-2-iodo-aniline serves as a versatile tri-substituted aniline building block for palladium-catalyzed cross-coupling reactions. The orthogonal reactivity of bromo, fluoro, and iodo groups enables sequential functionalization in late-stage diversification. Bench-stable and compatible with standard coupling protocols, it facilitates the synthesis of complex aryl scaffolds relevant to medicinal chemistry and materials science.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.775
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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