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CS-W001157 4
Total: USD 88.00

(2,3-Difluoropyridin-4-yl)boronic acid

  • CAS No. 1263374-42-0

  • Cat. No. CS-0028744
  • Purity≥97%
  • MDL No.MFCD12022339

*For research and further manufacturing use only, not for direct human use.

(2,3-Difluoropyridin-4-yl)boronic acid|CS-0028744

Structure of 1263374-42-0

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General Information

  • CAS No. 1263374-42-0
  • Cat. No. CS-0028744
  • Purity ≥97%
  • MDL No. MFCD12022339
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄BF₂NO₂
  • Molecular Weight 158.90
  • Synonym(s) 1-Propanol,2,3-difluoro-,acetate
  • SMILES FC1=C(B(O)O)C=CN=C1F

Description

This boronate moiety features a difluoropyridine scaffold, delivering enhanced stability and tunable reactivity in cross-coupling processes. The electron-deficient pyridine ring promotes efficient Suzuki-Miyaura coupling under standard conditions, enabling rapid access to fluorinated heteroaryl architectures.

Application

(2,3-Difluoropyridin-4-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biologically relevant heteroaryl architectures. Its fluorinated pyridine core offers enhanced metabolic stability and tunable electronic properties, while the boronic acid functionality provides excellent bench stability and compatibility with diverse reaction conditions. The compound facilitates rapid access to complex molecular scaffolds with high functional group tolerance and straightforward purification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   -0.9604
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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